Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953146 | 0.90 | HPSE (0.45) | CHEK2AMY1AHPSE | |
| SCHEMBL7049004 | 0.86 | CHEK2 (0.43) | CHEK2AMY1AHPSECHEK1 | |
| SCHEMBL6284709 | 0.85 | CHEK2 (0.38) | CHEK2HPSECHEK1 | |
| SCHEMBL6283906 | 0.81 | CHEK2 (0.40) | CHEK2CHEK1 | |
| SCHEMBL5952131 | 0.81 | AMY1A (0.41) | CHEK2RHEBAMY1APTGDR2MAP3K8 | |
| SCHEMBL5952114 | 0.80 | HPSE (0.41) | CHEK2RHEBAMY1APTGDR2HPSE | |
| SCHEMBL13374062 | 0.79 | MAPT (0.43) | RHEBAMY1APTGDR2HPSECHEK1 | |
| SCHEMBL5952676 | 0.79 | HPSE (0.46) | AMY1AHPSE | |
| SCHEMBL5952046 | 0.77 | NPBWR1 (0.46) | AMY1APTGDR2MAP3K8 | |
| SCHEMBL13373910 | 0.75 | JAK2 (0.45) | RHEBHPSECHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |