⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728836 | 0.79 | — | — | |
| SCHEMBL7268513 | 0.76 | — | — | |
| SCHEMBL10677104 | 0.73 | — | — | |
| SCHEMBL7471040 | 0.73 | — | — | |
| SCHEMBL263794 | 0.67 | — | — | |
| SCHEMBL4533789 | 0.67 | — | — | |
| Tert-Butylamine SCHEMBL6064515 | 0.65 | FDPS (0.33) | — | |
| SCHEMBL111550 | 0.65 | — | — | |
| Tert-Butylamine SCHEMBL5736553 | 0.65 | — | — | |
| SCHEMBL94353 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334166-A1 | BARRIER LAMINATE, GAS BARRIER FILM, AND DEVICE EMPLOYING THE SAME | FUJIFILM CORPORATION (JP) | 2017-11-23 | — | — | US | disclosed |
| EP-3154959-A1 | 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | Array Biopharma, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015175788-A1 | 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | ARRAY BIOPHARMA INC. (US) | 2015-11-19 | — | — | WO | disclosed |
| EP-2922844-A1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014078323-A1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| US-6919291-B2 | Fluorinated zwitterionic cocatalyst activators for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040110631-A1 | Fluorinated zwitterionic cocatalyst activators for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-06-10 | — | — | US | disclosed |
| EP-1349653-A2 | FLUORINATED ZWITTERIONIC COCATALYST ACTIVATORS FOR OLEFIN POLYMERIZATION | ExxonMobil Chemical Patents Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002036639-A2 | FLUORINATED ZWITTERIONIC COCATALYST ACTIVATORS FOR OLEFIN POLYMERIZATION | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-05-10 | — | — | WO | disclosed |