Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 5/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284735 | 1.00 | RORC (0.39) | RORCFGFR1KDRALDH1A1HSP90AA1 | |
| SCHEMBL5247183 | 0.69 | KDR (0.70) | FGFR1KDRLCK | |
| SCHEMBL5247178 | 0.69 | KDR (0.70) | FGFR1KDRLCK | |
| SCHEMBL30792324 | 0.69 | CNR1 (0.50) | FGFR1ALDH1A1MEN1NPC1RAB9A | |
| Phthalic Acid SCHEMBL11600688 | 0.67 | KDM4E (0.50) | ALDH1A1HSP90AA1MEN1NPC1RAB9A | |
| SCHEMBL6282592 | 0.65 | ELANE (0.53) | RORCELANEF2 | |
| SCHEMBL709588 | 0.63 | MEN1 (0.55) | KDRALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL709589 | 0.63 | MEN1 (0.55) | KDRALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL5331216 | 0.63 | ELANE (0.43) | RORCELANEF2 | |
| SCHEMBL2998381 | 0.63 | PTGS1 (0.60) | KDRALDH1A1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |