Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.53 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 4/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4153026 | 0.74 | NFE2L2 (0.49) | ELANE | |
| SCHEMBL28179497 | 0.73 | TTR (0.59) | — | |
| SCHEMBL4319960 | 0.69 | ELANE (0.50) | ELANEF2PLAURORC | |
| SCHEMBL4319958 | 0.69 | ELANE (0.50) | ELANEF2PLAURORC | |
| SCHEMBL6496546 | 0.68 | KDR (0.53) | — | |
| SCHEMBL5249781 | 0.68 | KDR (0.82) | — | |
| SCHEMBL10707481 | 0.68 | LMNA (0.57) | ELANE | |
| SCHEMBL11012522 | 0.66 | ELANE (0.62) | ELANEF2PLAUCTRB1RORC | |
| SCHEMBL5518387 | 0.66 | L3MBTL1 (0.43) | RORC | |
| Terephthalamide SCHEMBL11494225 | 0.66 | MAPT (0.58) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |