Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285417 | 0.79 | HDAC1 (0.38) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6050169 | 0.78 | CYP2D6 (0.65) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6285601 | 0.74 | CYP2D6 (0.42) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6286308 | 0.71 | L3MBTL1 (0.43) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6188908 | 0.70 | TDP1 (0.41) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6645849 | 0.69 | L3MBTL1 (0.45) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6050132 | 0.69 | NOS2 (0.46) | CYP2D6SLC6A2SLC6A4NOS2L3MBTL1 | |
| SCHEMBL22957517 | 0.68 | L3MBTL1 (0.57) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL6186905 | 0.67 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 | |
| SCHEMBL4011612 | 0.66 | L3MBTL1 (0.51) | CYP2D6SLC6A2SLC6A4NOS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2005501834-A | — | — | 2005-01-20 | — | — | JP | claimed |
| EP-1414802-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003011830-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | claimed |
| EP-1414802-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011830-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | disclosed |