Sugi Predict

Sugi Predict / Compounds / SCHEMBL6284923

SCHEMBL6284923

SCHEMBL6284923

CC(C)(C)OC(=O)N=C(N)N(CCCCCN)C(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CA14 Q9ULX7 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ HDAC6 Q9UBN7 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.30
▸ CHRM2 P08172 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5836122 0.99 CA14 (0.33) CA14HDAC1HDAC2HDAC6
SCHEMBL5846398 0.94 CA14 (0.31) CA14HDAC1HDAC2HDAC6
SCHEMBL5846385 0.94 CA14 (0.31) CA14HDAC1HDAC2HDAC6
SCHEMBL991813 0.94 HDAC1 (0.36) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL3488587 0.89 TDP1 (0.38) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL343348 0.83 HDAC6 (0.40) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL3795164 0.83 HDAC6 (0.40) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL136317 0.83 HDAC6 (0.40) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL1906455 0.83 HDAC6 (0.40) CA14HDAC1HDAC2HDAC6L3MBTL1
SCHEMBL865291 0.83 HDAC6 (0.40) CA14HDAC1HDAC2HDAC6L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6852761-B2 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade PHARMACIA CORPORATION (US) 2005-02-08 — — US disclosed
US-20040138275-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-20030236231-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade PHARMACIA CORPORATION 2003-12-25 — — US disclosed
US-6660885-B2 Serine protease inhibitor PHARMACIA CORPORATION 2003-12-09 — — US disclosed
US-20020025947-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade PHARMACIA CORPORATION 2002-02-28 — — US disclosed
WO-2001068605-A1 POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED BENZENES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE PHARMACIA CORPORATION (US) 2001-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236231-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade TFPI, TFPI2, PLAT CA14 2048/4885HDAC1 1439/4885HDAC2 1313/4885
US-20040138275-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade TFPI, TFPI2, PLAT CA14 2048/4885HDAC1 1439/4885HDAC2 1313/4885
US-20020025947-A1 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade TFPI, TFPI2, PLAT CA14 2048/4885HDAC1 1439/4885HDAC2 1313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.