SCHEMBL6285219

SCHEMBL6285219

CC1(c2ccccc2)C(=O)N(C(=O)c2cccc3ccccc23)C(=O)N1Cc1cccc(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FNTA P49354 5/20 0.50
FNTB P49356 5/20 0.50
DRD4 P21917 1/20 0.43
TACR1 P25103 1/20 0.42
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
CTSV O60911 1/20 0.40
CTSL P07711 1/20 0.40
CTSB P07858 1/20 0.40
CTSS P25774 1/20 0.40
AMPD2 Q01433 1/20 0.40
CCR2 P41597 1/20 0.39
HCRTR1 O43613 1/20 0.38
FSCN1 Q16658 1/20 0.38
AVPR1A P37288 1/20 0.38
FFAR2 O15552 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6285484 0.88 FNTA (0.47) FNTAFNTBDRD4TACR1KMT2A
SCHEMBL6285454 0.86 CNR2 (0.45) FNTAFNTBTACR1KMT2AMEN1
SCHEMBL6285229 0.85 DRD4 (0.43) FNTAFNTBDRD4AMPD2CCR2
SCHEMBL6282910 0.81 BCHE (0.41) FNTAFNTBTACR1KMT2AMEN1
SCHEMBL6283110 0.80 AVPR1A (0.44) DRD4TACR1KMT2AMEN1AVPR1A
SCHEMBL6285241 0.79 CBX7 (0.40) FNTAFNTBTACR1KMT2AMEN1
SCHEMBL6282969 0.79 CNR2 (0.49) FNTAFNTBDRD4TACR1KMT2A
SCHEMBL6287289 0.73 BCHE (0.41) TACR1AVPR1A
SCHEMBL6285489 0.72 DRD4 (0.46) FNTAFNTBDRD4KMT2AAMPD2
SCHEMBL6278686 0.71 BCHE (0.43) TACR1KMT2AMEN1AVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6919365-B2 Imidazolidinedione derivatives and use thereof as drugs SENJU PHARMACEUTICAL CO., LTD. (JP) 2005-07-19 US disclosed
US-20040110811-A1 Novel imidazolidinedione derivatives and use thereof as drugs SENJU PHARMACEUTICAL CO., LTD. (JP) 2004-06-10 US disclosed
EP-1384715-A1 NOVEL IMIDAZOLIDINEDIONE DERIVATIVES AND USE THEREOF AS DRUGS Senju Pharmaceutical Co., Ltd. (JP) 2004-01-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110811-A1 Novel imidazolidinedione derivatives and use thereof as drugs CMA1, TPSD1, TPSB2 FNTA 4765/4885FNTB 4212/4885DRD4 182/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.