Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.79 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 4/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281775 | 0.92 | CNR1 (0.82) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6278428 | 0.88 | CNR1 (1.00) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6279138 | 0.88 | CNR1 (0.77) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6279016 | 0.87 | CNR1 (0.67) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6282391 | 0.86 | CNR1 (0.74) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6284850 | 0.85 | CNR1 (0.72) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6278409 | 0.84 | CNR1 (0.70) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6282681 | 0.84 | CNR1 (0.70) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL24232752 | 0.82 | CNR1 (0.67) | CNR1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL6285020 | 0.82 | KDR (0.67) | CNR1KDRGSTO1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PEVARELLO PAOLO (IT) | 2004-08-12 | — | — | US | claimed |
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | claimed |
| US-6863647-B2 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2005-03-08 | — | — | US | disclosed |
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PEVARELLO PAOLO (IT) | 2004-08-12 | — | — | US | disclosed |
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | CNR1 1317/4885KDR 622/4885GSTO1 3939/4885 |
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | CNR1 1317/4885KDR 622/4885GSTO1 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.