Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 12/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 6/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280843 | 0.81 | HRH4 (0.46) | MAPK14HRH4 | |
| SCHEMBL6286431 | 0.77 | MAPK9 (0.42) | MAPK14MALT1CDC7HRH4KDM4E | |
| SCHEMBL6286429 | 0.68 | MAPK9 (0.41) | MAPK14PRKD1HRH4KDM4EALDH1A1 | |
| SCHEMBL19519007 | 0.63 | HRH4 (0.72) | HRH4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL827883 | 0.63 | ALDH1A1 (0.83) | MALT1HRH4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL16974188 | 0.63 | ALDH1A1 (0.53) | MAPK14MALT1CDC7HRH4KDM4E | |
| SCHEMBL2710597 | 0.63 | ALDH1A1 (0.53) | MAPK14MALT1CDC7HRH4KDM4E | |
| SCHEMBL2434811 | 0.63 | ALDH1A1 (0.53) | MAPK14MALT1HRH4KDM4EALDH1A1 | |
| SCHEMBL1579509 | 0.62 | PRKD1 (0.66) | PRKD1PRKD2CDC7KDM4EALDH1A1 | |
| SCHEMBL1192258 | 0.62 | CCNT1 (0.55) | MAPK14PRKD1PRKD2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |