Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 6/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286429 | 0.84 | MAPK9 (0.41) | MAPK9MAPK10MAPK8KDM4EALDH1A1 | |
| SCHEMBL6285627 | 0.77 | MAPK14 (0.40) | KDM4EALDH1A1L3MBTL1MALT1HRH4 | |
| SCHEMBL6285213 | 0.73 | HTT (0.38) | MAPK9MAPK10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6280409 | 0.72 | ADORA2A (0.34) | MAPK10ALDH1A1 | |
| SCHEMBL11391249 | 0.70 | POLB (0.49) | MAPK9MAPK8KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL827883 | 0.66 | ALDH1A1 (0.83) | KDM4EALDH1A1L3MBTL1MALT1HRH4 | |
| SCHEMBL19519007 | 0.63 | HRH4 (0.72) | KDM4EALDH1A1L3MBTL1HRH4 | |
| SCHEMBL15830500 | 0.63 | KDM4E (0.71) | KDM4EALDH1A1L3MBTL1HRH4NOS1 | |
| SCHEMBL2710597 | 0.63 | ALDH1A1 (0.53) | KDM4EALDH1A1L3MBTL1MALT1HRH4 | |
| SCHEMBL16974188 | 0.63 | ALDH1A1 (0.53) | MAPK9MAPK10MAPK8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |