Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288497 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL6283300 | 0.77 | KDM4E (0.33) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL6283496 | 0.76 | ALDH1A1 (0.37) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL6279480 | 0.76 | — | — | |
| SCHEMBL6282909 | 0.75 | — | — | |
| SCHEMBL6287861 | 0.71 | KDM4E (0.36) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL2273081 | 0.70 | NPC1 (0.40) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL6282842 | 0.68 | — | — | |
| SCHEMBL2268373 | 0.66 | NPC1 (0.34) | ALDH1A1NPC1RAB9AMAPK1AKT1 | |
| SCHEMBL13860530 | 0.66 | MAPT (0.57) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923929-B1 | KERATIN FIBRE DYE COMPOSITION CONTAINING PYRAZOLO-AZOLE COMPOUNDS, USE THEREOF AS OXIDATION AGENTS, AND DYEING METHOD; PYRAZOLOAZOLES | OREAL (FR) | 2004-05-12 | — | — | EP | claimed |
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'OREAL | 2002-10-24 | — | — | US | claimed |
| US-6379397-B2 | CAPABLE OF GENERATING INTENSE COLORINGS IN VARIED SHADES | L'OREAL S.A. (FR) | 2002-04-30 | — | — | US | claimed |
| US-6855827-B2 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'ORÉAL (FR) | 2005-02-15 | — | — | US | disclosed |
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'OREAL | 2002-10-24 | — | — | US | disclosed |
| US-6379397-B2 | CAPABLE OF GENERATING INTENSE COLORINGS IN VARIED SHADES | L'OREAL S.A. (FR) | 2002-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | KRT18, ZYX, TUBB3 | ALDH1A1 264/4885NPC1 4587/4885RAB9A 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.