SCHEMBL6287038

SCHEMBL6287038

FC(F)(F)c1ccc(C2=Cc3ccccc3C2[Zr](Cl)(Cl)C2C(c3ccc(C(F)(F)F)cc3)=Cc3ccccc32)cc1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 6/20 0.41
BACE1 P56817 1/20 0.36
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
CHUK O15111 1/20 0.30
TXNRD1 Q16881 1/20 0.30
NOX4 Q9NPH5 1/20 0.30
SCN2A Q99250 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6290545 0.87 CNR1 (0.33)
SCHEMBL6927240 0.86 CNR1 (0.34) KIF11BACE1ALDH1A1TSHR
SCHEMBL6285520 0.85 PTAFR (0.33) KIF11ALDH1A1TSHR
SCHEMBL6287310 0.83 HTR2C (0.31)
SCHEMBL6287549 0.83 CYP1A2 (0.33) ALDH1A1
SCHEMBL1681584 0.82
SCHEMBL6287249 0.81 RGS4 (0.31) ALDH1A1MAPT
SCHEMBL27468527 0.78 KIF11 (0.46) KIF11BACE1ALDH1A1TSHRCHUK
SCHEMBL1980941 0.77 KIF11 (0.41) KIF11BACE1ALDH1A1TSHRCHUK
SCHEMBL395081 0.77 KIF11 (0.41) KIF11BACE1ALDH1A1TSHRCHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6960550-B2 Catalyst systems for high melting thermoplastic elastomeric α-olefin polymers and plastomers THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2005-11-01 US disclosed
US-20030195308-A1 Catalyst systems for high melting thermoplastic elastomeric alpha-olefin polymers and plastomers THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2003-10-16 US disclosed
US-6566544-B1 Indene ring-containing metallocene-complex catalysts THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY 2003-05-20 US disclosed
EP-0991675-A4 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC ALPHA-OLEFIN POLYMERS (PRE/EPE EFFECTS) UNIV LELAND STANFORD JUNIOR (US) 2002-07-03 EP disclosed
US-6160064-A POLYMERIZING MONOMERS IN PRESENCE OF CATALYST SYSTEM COMPRISING UNBRIDGED FLUXIONAL METALLOCENE AND COCATALYST, INTRODUCING ETHYLENE INTO SYSTEM TO INDUCE POLYMERIZATION RATE ENHANCEMENT/ELASTOMERIC PROPERTY ENHANCING EFFECTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-12-12 US disclosed
EP-0745099-B1 REACTOR BLEND POLYPROPYLENE AND PROCESS FOR THE PREPARATION THEREOF MONTELL TECHNOLOGY COMPANY BV (NL) 2000-09-13 EP disclosed
US-6107431-A CATALYTIC POLYMERIZATION OF POLYPROPYLENE THERMOPLASTIC ELASTOMER USING ALUMOXANE-METALLOCENE DERIVATIVE CATALYST MONTELL TECHNOLOGY COMPANY BV (NL) 2000-08-22 US disclosed
EP-0991675-A1 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC $g(a)-OLEFIN POLYMERS (PRE/EPE EFFECTS) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-04-12 EP disclosed
WO-1998057996-A1 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC α-OLEFIN POLYMERS (PRE/EPE EFFECTS) THE BOARD OF TRUSTEES OF THE LELAND STANFORD, JR. UNIVERSITY (US) 1998-12-23 WO disclosed
EP-0745099-A1 REACTOR BLEND POLYPROPYLENE, PROCESS FOR THE PREPARATION THEREOF AND PROCESS FOR PREPARING METALLOCENE LIGANDS Montell Technology Company bv (NL) 1996-12-04 EP disclosed
WO-1996020225-A2 REACTOR BLEND POLYPROPYLENE, PROCESS FOR THE PREPARATION THEREOF AND PROCESS FOR PREPARING METALLOCENE LIGANDS MONTELL TECHNOLOGY COMPANY B.V. (NL) 1996-07-04 WO disclosed