Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | CCR9 | P51686 | 15/20 | 0.49 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749 | 0.89 | LMNA (0.63) | LMNAHTTCCR9TP53MAPT | |
| SCHEMBL28849 | 0.85 | LMNA (0.74) | LMNAHTTCCR9BDKRB1TP53 | |
| SCHEMBL13077691 | 0.79 | LMNA (0.56) | LMNAHTTCCR9BDKRB1TP53 | |
| SCHEMBL27486 | 0.79 | LMNA (0.72) | LMNAHTTCCR9TP53MAPT | |
| SCHEMBL6288122 | 0.78 | C5AR1 (0.45) | LMNAHTTCCR9TP53MAPT | |
| SCHEMBL28407 | 0.78 | LMNA (0.46) | LMNAHTTCCR9CCR2 | |
| SCHEMBL27973 | 0.76 | LMNA (0.51) | LMNAHTTCCR9BDKRB1KMT2A | |
| SCHEMBL10223700 | 0.75 | CCR2 (0.44) | LMNAHTTCCR9CCR2 | |
| SCHEMBL28625 | 0.75 | BDKRB1 (0.76) | LMNAHTTCCR9BDKRB1TP53 | |
| SCHEMBL13077434 | 0.75 | LMNA (0.65) | LMNAHTTCCR9BDKRB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005112916-A2 | BIS-ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2005-12-01 | — | — | WO | disclosed |