Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291873 | 0.91 | MAPT (0.31) | MAPTTP53POLBADORA3ALDH1A1 | |
| SCHEMBL6291360 | 0.89 | LMNA (0.32) | TP53ALDH1A1 | |
| SCHEMBL6288364 | 0.86 | GRM7 (0.39) | MAPTTP53ALDH1A1 | |
| SCHEMBL6291459 | 0.83 | S1PR1 (0.37) | MAPTTP53 | |
| SCHEMBL6288381 | 0.82 | LMNA (0.34) | MAPTTP53POLBADORA3ALDH1A1 | |
| SCHEMBL6291357 | 0.79 | SMN1; SMN2 (0.39) | MAPTTP53POLBADORA3ALDH1A1 | |
| SCHEMBL6291832 | 0.76 | GRM7 (0.41) | MAPTTP53POLBALDH1A1 | |
| SCHEMBL8361378 | 0.75 | ALDH1A1 (0.42) | MAPTPOLBALDH1A1 | |
| SCHEMBL6288552 | 0.75 | GRM7 (0.38) | MAPTTP53 | |
| SCHEMBL5620144 | 0.73 | AHR (0.36) | MAPTADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936609-B2 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2005-08-30 | — | — | US | disclosed |