Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288516 | 0.72 | S1PR2 (0.39) | ALDH1A1KDM4EHPGDMEN1CYP1A2 | |
| SCHEMBL19437829 | 0.70 | CSNK1D (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL14640582 | 0.69 | MAPT (0.58) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL18355564 | 0.69 | JAK2 (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL19438100 | 0.69 | CSNK1D (0.46) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL3342312 | 0.66 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL20028187 | 0.66 | JAK2 (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL2017634 | 0.66 | CYP1A2 (0.55) | ALDH1A1KDM4EHPGDCYP1A2CYP2C9 | |
| SCHEMBL9585774 | 0.65 | JMJD6 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL1765415 | 0.65 | CHRNA7 (0.64) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900223-B2 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | CD274, PDCD1, PDCD1LG2 | ALDH1A1 53/4885KDM4E 799/4885HPGD 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.