Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 4/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288518 | 0.82 | SMN1; SMN2 (0.40) | S1PR2ALDH1A2ALDH1A3TRPM8KDM4E | |
| SCHEMBL6701828 | 0.73 | KDM4E (0.49) | CSNK1DKDM4EALDH1A1HSD17B10GPBAR1 | |
| SCHEMBL6288517 | 0.72 | ALDH1A1 (0.42) | CSNK1DJAK2JAK3TRPM8KDM4E | |
| SCHEMBL6288769 | 0.71 | MAPT (0.39) | S1PR2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL16877267 | 0.68 | JAK2 (0.49) | CSNK1DJAK2JAK3TRPM8KDM4E | |
| SCHEMBL21268560 | 0.67 | CSNK1D (0.49) | CSNK1DJAK2JAK3TRPM8KDM4E | |
| SCHEMBL20028187 | 0.67 | JAK2 (0.55) | CSNK1DJAK2JAK3TRPM8KDM4E | |
| SCHEMBL6290563 | 0.65 | ALDH1A1 (0.57) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL14640582 | 0.65 | MAPT (0.58) | CSNK1DTRPM8KDM4EALDH1A1DHODH | |
| SCHEMBL28477674 | 0.64 | ADORA2B (0.58) | CSNK1DJAK2JAK3TRPM8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900223-B2 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | CD274, PDCD1, PDCD1LG2 | S1PR2 691/4885ALDH1A2 465/4885ALDH1A3 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.