Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561576 | 0.86 | KDM5A (0.57) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL16059192 | 0.85 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL6290024 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL14195210 | 0.73 | KDM5A (0.76) | ALDH1A1KDM4EKDM5AKDM5BCSF1R | |
| SCHEMBL1056675 | 0.73 | KDM5A (0.65) | ALDH1A1KDM4EKDM5AKDM5BCSF1R | |
| SCHEMBL4851362 | 0.73 | CSF1R (0.50) | ALDH1A1KDM4EHPGDKDM5AKDM5B | |
| SCHEMBL1061379 | 0.72 | KDM4E (0.64) | ALDH1A1KDM4ERAB9AKDM5AKDM5B | |
| SCHEMBL16058273 | 0.72 | KDM5A (0.53) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL4856086 | 0.72 | DAO (0.45) | ALDH1A1KDM4EKDM5AKDM5BCSF1R | |
| SCHEMBL15878812 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDRAB9AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900223-B2 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | CD274, PDCD1, PDCD1LG2 | ALDH1A1 53/4885KDM4E 799/4885HPGD 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.