Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058273 | 0.87 | KDM5A (0.53) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL6288527 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL16059054 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL16058050 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM4ERAB9AKDM5AKDM5B | |
| SCHEMBL19184473 | 0.76 | PDE9A (0.43) | PDE9A | |
| SCHEMBL8229160 | 0.74 | PDE4B (0.42) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL12499191 | 0.73 | PDE4B (0.42) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL561576 | 0.72 | KDM5A (0.57) | ALDH1A1KDM4EHPGDRAB9AHIF1A | |
| SCHEMBL17610218 | 0.71 | PDE9A (0.39) | KDM4EKDM5AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14195210 | 0.70 | KDM5A (0.76) | ALDH1A1KDM4EKDM5AKDM5BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970266-B1 | 1-PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-01-31 | — | — | EP | disclosed |
| EP-2970266-B1 | 1-PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-01-31 | — | — | EP | disclosed |
| US-20170283440-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-10-05 | — | — | US | disclosed |
| US-20170283440-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-10-05 | — | — | US | disclosed |
| US-9718816-B2 | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718816-B2 | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-08-01 | — | — | US | disclosed |
| WO-2016044650-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044650-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20160052922-A1 | 1-PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme. Inc. (US) | 2016-02-25 | — | — | US | disclosed |
| EP-2970266-A1 | 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144455-A1 | 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144455-A1 | 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052922-A1 | 1-PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | CARM1, ADRM1, PBRM1 | ALDH1A1 951/4885KDM4E 593/4885HPGD 3520/4885 |
| US-20170283440-A1 | CARM1 INHIBITORS AND USES THEREOF | CARM1, ADRM1, TIAM1 | ALDH1A1 1277/4885KDM4E 475/4885HPGD 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.