Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288398 | 0.89 | ALDH1A1 (0.42) | PDE10AALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6291358 | 0.88 | CNR2 (0.35) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6288657 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6291357 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6288422 | 0.78 | BRD4 (0.47) | ALDH1A1RAB9AHSD17B10CNR2PDE5A | |
| SCHEMBL6291399 | 0.73 | POLB (0.37) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6288381 | 0.72 | LMNA (0.34) | SMN1; SMN2ALDH1A1KDM4ENPC1TP53 | |
| SCHEMBL6288587 | 0.72 | GRM7 (0.44) | SMN1; SMN2NPC1TP53RAB9AMAPT | |
| SCHEMBL6291858 | 0.71 | MEN1 (0.40) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL5620144 | 0.71 | AHR (0.36) | ALDH1A1HPGDKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936609-B2 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | PDE3A, PDE2A, PDE4A | PDE10A 20/4885SMN1; SMN2 553/4885ALDH1A1 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.