Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288423 | 0.96 | ALOX15 (0.46) | ABCG2ABCB1ABCC1ALOX15NPC1 | |
| SCHEMBL6291366 | 0.92 | EPHB4 (0.44) | ABCG2ABCB1ABCC1ALOX15GAA | |
| SCHEMBL6288409 | 0.85 | ABCG2 (0.48) | ABCG2ABCB1ABCC1NPC1RAB9A | |
| SCHEMBL6287805 | 0.85 | PLK1 (0.45) | ABCG2ABCB1ABCC1MAPTGAA | |
| SCHEMBL6288410 | 0.82 | ABCG2 (0.42) | ABCG2ABCB1ABCC1NPC1RAB9A | |
| SCHEMBL6291395 | 0.81 | BCL6 (0.42) | ABCG2ABCB1ABCC1ALOX15NPC1 | |
| SCHEMBL6288637 | 0.79 | KDM4E (0.45) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL6291417 | 0.79 | PLK1 (0.45) | MAPTGAAPLK1MEN1KMT2A | |
| SCHEMBL5916437 | 0.78 | PLK1 (0.45) | GAAPLK1 | |
| SCHEMBL5619503 | 0.78 | PLK1 (0.46) | MAPTGAAPLK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936609-B2 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1404677-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000693-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2003-01-03 | — | — | WO | disclosed |