Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.65 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128458 | 0.88 | PTGS1 (0.61) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL6513465 | 0.87 | PTGS1 (0.60) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL3674440 | 0.86 | AKR1C3 (0.70) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL28133951 | 0.84 | PTGS1 (0.65) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL4740646 | 0.83 | PTGS1 (0.63) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL3673447 | 0.83 | PTGS1 (0.63) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL2745203 | 0.82 | PTGS1 (0.58) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL954605 | 0.82 | PTGS1 (0.58) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL3668050 | 0.82 | PTGS1 (0.61) | PTGS1AKR1C3AKR1C2PTGS2SMN1; SMN2 | |
| SCHEMBL2986567 | 0.82 | ALOX5 (0.67) | PTGS1PTGS2SMN1; SMN2MAPTCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838584-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2005-01-04 | — | — | US | disclosed |
| US-20040162304-A1 | Estrogen receptor modulators | MERCK & CO., INC. | 2004-08-19 | — | — | US | disclosed |
| EP-1387821-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002091993-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162304-A1 | Estrogen receptor modulators | ESRRA, GPER1, ESRRB | PTGS1 234/4885AKR1C3 649/4885AKR1C2 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.