Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288688 | 0.91 | EGFR (0.39) | OPRM1OPRL1MMP2MMP3MMP9 | |
| SCHEMBL22323576 | 0.91 | EGFR (0.39) | OPRM1OPRL1MMP2MMP3MMP9 | |
| SCHEMBL9182623 | 0.84 | HCAR3 (0.42) | ELANEHSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22323616 | 0.78 | EGFR (0.42) | HSD11B1CYP2C9EGFRMEN1KMT2A | |
| SCHEMBL19419818 | 0.78 | EGFR (0.42) | HSD11B1CYP2C9EGFRMEN1KMT2A | |
| SCHEMBL11140706 | 0.75 | OPRM1 (0.46) | OPRM1OPRL1ELANEMMP2MMP3 | |
| SCHEMBL24157978 | 0.74 | GAA (0.40) | — | |
| SCHEMBL24157980 | 0.73 | GAA (0.50) | OPRM1MEN1KMT2AL3MBTL1 | |
| SCHEMBL24157976 | 0.72 | KCNA3 (0.40) | OPRM1HSD11B1NPSR1EGFRMEN1 | |
| SCHEMBL6604509 | 0.71 | EGFR (0.37) | OPRM1OPRL1ELANEMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956055-B2 | Substituted γ-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2005-10-18 | — | — | US | disclosed |