Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6288873 | 1.00 | CHRM2 (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL4769349 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTGAA | |
| Oxalic Acid SCHEMBL4769354 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTGAA | |
| SCHEMBL4769370 | 0.81 | KDM4E (0.38) | LMNAALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL4769372 | 0.81 | KDM4E (0.38) | LMNAALDH1A1KDM4EKMT2AMAPT | |
| Oxalic Acid SCHEMBL4772880 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4EKMT2AMAPTGAA | |
| Oxalic Acid SCHEMBL4772888 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4EKMT2AMAPTGAA | |
| SCHEMBL4792963 | 0.73 | MAPT (0.41) | LMNAALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL4792970 | 0.73 | MAPT (0.41) | LMNAALDH1A1KDM4EKMT2AMAPT | |
| Oxalic Acid SCHEMBL4769148 | 0.72 | KDM4E (0.46) | LMNAALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875761-B2 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |