Dimethylamine

Dimethylamine

SCHEMBL6289065

CNC.Cc1cccc(C(=O)C[S+](C)C)c1.[Br-]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Dimethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.49
TDP1 Q9NUW8 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
PARP1 P09874 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
CTNNB1 P35222 3/20 0.46
WNT3A P56704 3/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
KDM4E B2RXH2 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
KCNK3 O14649 2/20 0.45
KCNK9 Q9NPC2 2/20 0.45
KCNH2 Q12809 1/20 0.45
POLB P06746 2/20 0.44
TAS1R3 Q7RTX0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL6289518 0.81 KMT2A (0.54) HPGDTDP1SMN1; SMN2MEN1KMT2A
SCHEMBL28728190 0.79 MEN1 (0.64) HPGDTDP1HDAC8HDAC6PARP1
SCHEMBL29456641 0.79 MEN1 (0.64) HPGDTDP1HDAC8HDAC6PARP1
SCHEMBL24229642 0.76 HDAC8 (0.55) HPGDTDP1HDAC8HDAC6PARP1
SCHEMBL29062364 0.75 CTNNB1 (0.70) HPGDTDP1HDAC8HDAC6PARP1
Bromide SCHEMBL394250 0.75 KMT2A (0.54) HPGDTDP1HDAC8HDAC6SMN1; SMN2
SCHEMBL30089541 0.75 CTNNB1 (0.70) HPGDTDP1HDAC8HDAC6PARP1
Bromide SCHEMBL6289517 0.74 KMT2A (0.49) HPGDHDAC6SMN1; SMN2KMT2AKDM4E
SCHEMBL3039881 0.74 HDAC8 (0.56) HPGDTDP1HDAC8HDAC6PARP1
SCHEMBL1421021 0.74 SMN1; SMN2 (0.58) HPGDTDP1HDAC8HDAC6PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6900250-B2 Polymerizable composition TOYO INK MFG. CO., LTD. (JP) 2005-05-31 US disclosed
US-20030212162-A1 Photopolymerization using photoinitiators TOYO INK MFG. CO., LTD. (JP) 2003-11-13 US disclosed