Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 12/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GCGR | P47871 | 2/20 | 0.54 |
| ▸ | GIPR | P48546 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289561 | 1.00 | CA1 (0.63) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL8461643 | 0.80 | CA1 (0.74) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL2653593 | 0.80 | NR1H4 (0.64) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL27578769 | 0.78 | NR1H4 (0.62) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL2643145 | 0.78 | CA1 (1.00) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL12326089 | 0.76 | PLK1 (0.54) | EPHX2RAB9ALMNAGCGRGIPR | |
| SCHEMBL2658279 | 0.76 | CA1 (0.67) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL17308777 | 0.76 | CA1 (0.80) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL5184746 | 0.75 | CA1 (0.70) | CA1CA2EPHX2NR1H4RAB9A | |
| SCHEMBL29129862 | 0.74 | NR1H4 (0.67) | CA1CA2EPHX2NR1H4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953812-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK, INC. (DK) | 2005-10-11 | — | — | US | disclosed |
| US-20040024045-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2004-02-05 | — | — | US | disclosed |
| US-6562807-B2 | For prophylaxis and therapy of hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity | NOVO NORDISK A/S (DK) | 2003-05-13 | — | — | US | disclosed |
| US-20020143186-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2002-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024045-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | CA1 4725/4885CA2 3711/4885EPHX2 3116/4885 |
| US-20020143186-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | CA1 4725/4885CA2 3711/4885EPHX2 3116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.