Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | GCGR | P47871 | 3/20 | 0.59 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.59 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.59 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.59 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.59 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.59 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.59 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.59 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.59 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578769 | 0.93 | NR1H4 (0.62) | NR1H4EPHX2CA1CA2LMNA | |
| SCHEMBL2658279 | 0.88 | CA1 (0.67) | NR1H4EPHX2CA1CA2LMNA | |
| SCHEMBL15942950 | 0.86 | RAB9A (0.65) | NR1H4EPHX2CA1CA2GCGR | |
| SCHEMBL2651174 | 0.84 | AGER (0.51) | CA1CA2GCGRLMNA | |
| SCHEMBL8461643 | 0.82 | CA1 (0.74) | NR1H4EPHX2CA1CA2LMNA | |
| SCHEMBL10631142 | 0.81 | SMN1; SMN2 (0.71) | NR1H4EPHX2CA1CA2GCGR | |
| SCHEMBL6289554 | 0.80 | CA1 (0.63) | NR1H4EPHX2CA1CA2GCGR | |
| SCHEMBL6289561 | 0.80 | CA1 (0.63) | NR1H4EPHX2CA1CA2GCGR | |
| SCHEMBL2650398 | 0.80 | NPC1 (0.59) | NR1H4EPHX2LMNARAB9AMEN1 | |
| SCHEMBL2653879 | 0.79 | GCGR (0.57) | NR1H4EPHX2GCGRADCY6ADCY3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| EP-1183229-B1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK AS (DK) | 2005-10-26 | — | — | EP | disclosed |
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2005-09-15 | — | — | US | disclosed |
| US-6875760-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2005-04-05 | — | — | US | disclosed |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-11-27 | — | — | US | disclosed |
| US-6503949-B1 | Treating Type 2 diabetes, hyperglycemia, impaired glucose tolerance or obesity | NORO NORDISK A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | NR1H4 157/4885EPHX2 3463/4885CA1 4464/4885 |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | GLP1R, GPR119, GCGR | NR1H4 157/4885EPHX2 3463/4885CA1 4464/4885 |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | NR1H4 157/4885EPHX2 3463/4885CA1 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.