Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.53 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660490 | 0.87 | HTT (0.57) | SMN1; SMN2HTTF2RL1NPC1ALDH1A1 | |
| SCHEMBL3628705 | 0.82 | HTT (0.68) | SMN1; SMN2HTTF2RL1NPC1ALDH1A1 | |
| SCHEMBL11961416 | 0.81 | HTT (0.59) | SMN1; SMN2HTTF2RL1NPC1MEN1 | |
| SCHEMBL3280882 | 0.81 | HTT (0.62) | SMN1; SMN2HTTF2RL1NPC1MEN1 | |
| SCHEMBL1294826 | 0.80 | HTT (0.50) | SMN1; SMN2HTTF2RL1NPC1MEN1 | |
| SCHEMBL7527957 | 0.79 | CES2 (0.48) | MTNR1AMTNR1BMEN1ALDH1A1KMT2A | |
| SCHEMBL885045 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2MTNR1AMTNR1BNPC1MEN1 | |
| SCHEMBL10577487 | 0.77 | HTT (0.62) | SMN1; SMN2HTTF2RL1NPC1ALDH1A1 | |
| SCHEMBL5431221 | 0.77 | HTT (0.62) | SMN1; SMN2HTTF2RL1NPC1ALDH1A1 | |
| SCHEMBL3175977 | 0.77 | HTT (0.61) | SMN1; SMN2HTTF2RL1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887867-B2 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. (US) | 2005-05-03 | — | — | US | disclosed |
| EP-1296960-A2 | 5H-2,3-BENZODIAZEPINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | Annovis, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020025958-A1 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. | 2002-02-28 | — | — | US | disclosed |
| WO-2001098280-A2 | 5H-2,3-BENZODIAZEPINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | ANNOVIS, INC. (US) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025958-A1 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | GRIN2A, GRIN3A, GABRE | SMN1; SMN2 1820/4885HTT 2267/4885MTNR1A 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.