Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289650 | 0.87 | SMN1; SMN2 (0.61) | HTTNPC1KDM4EPOLBF2RL1 | |
| SCHEMBL4659431 | 0.82 | L3MBTL1 (0.54) | NPC1CTBP2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3628705 | 0.82 | HTT (0.68) | HTTNPC1KDM4EPOLBF2RL1 | |
| SCHEMBL11961416 | 0.81 | HTT (0.59) | HTTNPC1KDM4EPOLBF2RL1 | |
| SCHEMBL10577487 | 0.81 | HTT (0.62) | HTTNPC1KDM4EPOLBF2RL1 | |
| SCHEMBL1294826 | 0.80 | HTT (0.50) | HTTNPC1KDM4EPOLBF2RL1 | |
| SCHEMBL4660584 | 0.80 | ALDH1A1 (0.56) | HTTNPC1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL1695235 | 0.79 | NPC1 (0.66) | HTTNPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4032340 | 0.79 | NPC1 (0.66) | HTTNPC1CTBP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4582402 | 0.78 | CES1 (0.52) | ALDH1A1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004166-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120528-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2007-10-25 | — | — | WO | disclosed |