Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019001 | 0.92 | ST14 (0.48) | ST14HRH1CSNK2A1ALDH1A1TSHR | |
| SCHEMBL2013324 | 0.86 | PARP10 (0.47) | ST14PRSS1PRSS2PRSS3HRH1 | |
| SCHEMBL508364 | 0.85 | CSNK2A1 (0.56) | ST14HRH1CSNK2A1ALDH1A1TSHR | |
| SCHEMBL6289958 | 0.84 | HRH1 (0.41) | HRH1ALDH1A1TSHRPARP10BCL2A1 | |
| SCHEMBL508271 | 0.83 | CSNK2A1 (0.54) | ST14HRH1CSNK2A1ALDH1A1TSHR | |
| SCHEMBL507747 | 0.83 | CSNK2A1 (0.54) | ST14HRH1CSNK2A1ALDH1A1TSHR | |
| SCHEMBL6290098 | 0.83 | HRH1 (0.41) | ST14PRSS1PRSS2PRSS3HRH1 | |
| SCHEMBL113742 | 0.80 | HRH3 (0.46) | ST14HRH1CSNK2A1ALDH1A1TSHR | |
| SCHEMBL6289092 | 0.80 | HRH1 (0.66) | ST14HRH1CSNK2A1HRH3 | |
| SCHEMBL24493089 | 0.77 | HRH3 (0.58) | HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |