Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.37 |
| ▸ | FURIN | P09958 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013324 | 0.84 | PARP10 (0.47) | HRH1ALDH1A1TSHRPARP10HRH3 | |
| SCHEMBL6289959 | 0.84 | ST14 (0.45) | HRH1ALDH1A1TSHRBCL2A1PARP10 | |
| SCHEMBL7539391 | 0.83 | ALDH1A1 (0.54) | HRH1ALDH1A1TSHRPARP10HRH3 | |
| SCHEMBL6290095 | 0.80 | HRH1 (0.40) | HRH1 | |
| SCHEMBL6289091 | 0.79 | HRH1 (0.66) | HRH1ALDH1A1TSHRHRH3 | |
| SCHEMBL17324128 | 0.76 | TEAD4 (0.42) | HRH1ALDH1A1PARP10HRH3PTPN1 | |
| SCHEMBL15573563 | 0.76 | SLC6A4 (0.53) | BCL2A1PARP10 | |
| SCHEMBL13478355 | 0.76 | SLC6A4 (0.53) | BCL2A1PARP10 | |
| SCHEMBL1065749 | 0.76 | EPHX2 (0.50) | PARP10 | |
| SCHEMBL1065750 | 0.76 | EPHX2 (0.50) | PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |