SCHEMBL629040

SCHEMBL629040

CCCCn1c(Cl)nc2ccccc21

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 3/20 0.67
LMNA P02545 1/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
GAA P10253 1/20 0.58
TSHR P16473 1/20 0.58
L3MBTL1 Q9Y468 2/20 0.55
MEN1 O00255 1/20 0.55
USP2 O75604 1/20 0.55
KMT2A Q03164 1/20 0.55
ALDH1A1 P00352 2/20 0.54
HTT P42858 1/20 0.54
KDM4E B2RXH2 1/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
POLB P06746 1/20 0.53
SLC9A1 P19634 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11268441 0.90 POLB (0.65) TLR8LMNASMN1; SMN2GAATSHR
SCHEMBL28154146 0.83 LMNA (0.60) TLR8LMNASMN1; SMN2GAAMEN1
SCHEMBL10005374 0.83 TLR8 (0.71) TLR8LMNASMN1; SMN2GAATSHR
SCHEMBL8314046 0.83 LMNA (0.56) TLR8LMNASMN1; SMN2GAATSHR
SCHEMBL1128817 0.82 HTT (0.62) LMNASMN1; SMN2GAAL3MBTL1MEN1
SCHEMBL17103028 0.82 LMNA (0.59) TLR8LMNASMN1; SMN2MEN1KMT2A
SCHEMBL10923541 0.81 ATM (0.57) LMNASMN1; SMN2TSHRL3MBTL1MEN1
SCHEMBL1022300 0.81 TLR8 (0.69) TLR8LMNASMN1; SMN2GAATSHR
SCHEMBL2343059 0.80 TLR8 (1.00) TLR8SMN1; SMN2GAATSHRHTT
SCHEMBL3840545 0.80 TLR8 (0.67) TLR8LMNASMN1; SMN2GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109824629-B Method for preparing 3-amino-5- (alpha-aminoethyl) tetrahydrofuran by using N-acetylglucosamine 南京工业大学 2022-12-09 CN disclosed
CN-107759543-A The ionic liquid-catalyzed degradation of chitosan of benzimidazole prepares 5 hydroxymethylfurfurals 天津工业大学 2018-03-06 CN disclosed
CN-102569210-A Semiconductor device packaging method and semiconductor device package NXP BV 2012-07-11 CN disclosed
EP-2453474-A1 Semiconductor device packaging method and semiconductor device package NXP B.V. (NL) 2012-05-16 EP disclosed
US-20120112351-A1 SEMICONDUCTOR DEVICE PACKAGING METHOD AND SEMICONDUCTOR DEVICE PACKAGE NXP B.V. (NL) 2012-05-10 US disclosed
EP-2421032-A1 Semiconductor Device Packaging Method and Semiconductor Device Package NXP B.V. (NL) 2012-02-22 EP disclosed