Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294996 | 0.78 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL6294520 | 0.75 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL6294999 | 0.75 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL6291711 | 0.72 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6291674 | 0.71 | CRHR1 (0.76) | CRHR1 | |
| SCHEMBL6295021 | 0.69 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL6361913 | 0.69 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL6291817 | 0.69 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL7673920 | 0.68 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6294441 | 0.68 | CRHR1 (0.62) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869955-B2 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| EP-1380298-A2 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders, anorexia, inflammation | Bristol-Myers Squibb Pharma Company (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030064993-A1 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders | WILDE RICHARD GERALD (US) | 2003-04-03 | — | — | US | disclosed |
| US-6399609-B1 | CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-06-04 | — | — | US | disclosed |
| US-6083948-A | TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC AND NEUROLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064993-A1 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders | CRH, CRHR1, CRHR2 | CRHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.