Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692579 | 0.83 | CA12 (0.59) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL3608296 | 0.82 | PTGS2 (0.50) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL2413 | 0.82 | CYP3A4 (0.54) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL22162812 | 0.82 | CA12 (0.58) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL30009937 | 0.81 | PTGS2 (0.66) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL404584 | 0.81 | PTGS2 (0.66) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL14696834 | 0.80 | CYP3A4 (0.52) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27435892 | 0.80 | CYP3A4 (0.52) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL14451001 | 0.79 | CA12 (0.56) | CA12CA2CA9KIF11PTGS2 | |
| SCHEMBL5377159 | 0.79 | CYP3A4 (0.69) | CA12CA2CA9KIF11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927216-B2 | Cyclic sulfonyl compounds as inhibitors of metalloproteases | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-08-09 | — | — | US | disclosed |