Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288716 | 0.78 | NPC1 (0.42) | MEN1KMT2A | |
| SCHEMBL7039605 | 0.74 | DDB1 (0.55) | ROCK2 | |
| SCHEMBL25153928 | 0.74 | TSHR (0.38) | KDM4EMEN1KMT2A | |
| SCHEMBL2369918 | 0.70 | HCAR3 (0.42) | ROCK2KDM4EMEN1KMT2A | |
| SCHEMBL29586307 | 0.69 | SYK (0.39) | ROCK2KDM4EMEN1KMT2A | |
| SCHEMBL28283911 | 0.69 | SYK (0.39) | ROCK2KDM4EMEN1KMT2A | |
| SCHEMBL28279538 | 0.68 | KDM4E (0.35) | KDM4EMEN1KMT2A | |
| SCHEMBL5847287 | 0.67 | KDM4E (0.46) | KDM4EMEN1KMT2A | |
| SCHEMBL22877113 | 0.67 | KDM4E (0.50) | KDM4EMEN1KMT2A | |
| SCHEMBL15933096 | 0.67 | LIPG (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956055-B2 | Substituted γ-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2005-10-18 | — | — | US | disclosed |