Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540980 | 0.82 | KDM4E (0.60) | ALDH1A1LMNAKDM4EMPO | |
| SCHEMBL11932742 | 0.79 | KDM4E (0.60) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL6299167 | 0.77 | GAA (0.52) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL15356177 | 0.76 | KDM4E (0.57) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL6299171 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDHTTKDM4E | |
| SCHEMBL11852024 | 0.75 | APOBEC3G (0.62) | ALDH1A1SMN1; SMN2HPGDKDM4EMAPT | |
| SCHEMBL11983439 | 0.72 | PARP1 (0.56) | PARP1KDM4ETSPO | |
| SCHEMBL9280731 | 0.72 | KDM4E (0.45) | ALDH1A1SMN1; SMN2HPGDHTTPARP1 | |
| SCHEMBL17383212 | 0.72 | RXFP1 (0.56) | ALDH1A1HPGDHTTPARP1KDM4E | |
| SCHEMBL22700984 | 0.71 | HTT (0.69) | ALDH1A1SMN1; SMN2HPGDHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |