Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299171 | 0.87 | ALDH1A1 (0.44) | GAAPLK1APOBEC3GALDH1A1HPGD | |
| SCHEMBL11852024 | 0.77 | APOBEC3G (0.62) | APOBEC3GALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL6294348 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDHTTKDM4EHSD17B10 | |
| SCHEMBL3540980 | 0.76 | KDM4E (0.60) | ALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL30493502 | 0.75 | ALDH1A1 (0.58) | GAAPLK1APOBEC3GALDH1A1KMT2A | |
| SCHEMBL9709253 | 0.75 | ALDH1A1 (0.58) | GAAPLK1APOBEC3GALDH1A1KMT2A | |
| SCHEMBL146503 | 0.74 | CYP1A2 (0.56) | GAAAPOBEC3GALDH1A1HPGDHTT | |
| SCHEMBL30057865 | 0.71 | MEN1 (0.43) | GAAPLK1APOBEC3GALDH1A1HPGD | |
| SCHEMBL8523462 | 0.71 | GAA (0.53) | GAAPLK1APOBEC3GALDH1A1HPGD | |
| SCHEMBL9280731 | 0.70 | KDM4E (0.45) | ALDH1A1HPGDHTTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |