Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6294447

C=CCCCC[SiH3].[Cl-].[Cl-].[Zr+2]

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
ALDH1A1 P00352 3/20 0.41
ABCC4 O15439 1/20 0.37
MAPT P10636 1/20 0.37
TRPA1 O75762 3/20 0.36
LPAR3 Q9UBY5 2/20 0.32
LMNA P02545 1/20 0.32
LPAR2 Q9HBW0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7560137 0.97 TSHR (0.48) TSHRALDH1A1ABCC4MAPTTRPA1
SCHEMBL5909792 0.94
SCHEMBL6418651 0.91 TSHR (0.52) TSHRALDH1A1ABCC4MAPTTRPA1
SCHEMBL12609397 0.91 TSHR (0.52) TSHRALDH1A1ABCC4MAPTTRPA1
SCHEMBL5909735 0.91 TSHR (0.52) TSHRALDH1A1ABCC4MAPTTRPA1
SCHEMBL29156747 0.91 TSHR (0.52) TSHRALDH1A1ABCC4MAPTTRPA1
SCHEMBL9559196 0.91
SCHEMBL692882 0.91
SCHEMBL29255850 0.91 TSHR (0.52) TSHRALDH1A1ABCC4MAPTTRPA1
Hydrochloric Acid SCHEMBL7560132 0.86 TSHR (0.48) TSHRALDH1A1ABCC4MAPTTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6852660-B2 Solid metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2005-02-08 US claimed
US-20030144436-A1 Coorination catalyst for polyalpha-olefins MITCHELL KENT E (US) 2003-07-31 US claimed
US-20020177676-A1 Method for making and using a metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY LP, A DELAWARE LIMITED PARTNERSHIP 2002-11-28 US claimed
WO-2002072641-A1 METHOD FOR MAKING AND USING A METALLOCENE CATALYST SYSTEM CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2002-09-19 WO claimed
US-5498581-A OLEFIN POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1996-03-12 US claimed
US-20050171305-A1 Solid metallocene catalyst system MITCHELL KENT E (US) 2005-08-04 US disclosed
US-6852660-B2 Solid metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2005-02-08 US disclosed
US-20030144436-A1 Coorination catalyst for polyalpha-olefins MITCHELL KENT E (US) 2003-07-31 US disclosed
US-6534609-B2 Making by combining an organoaluminoxane and a metallocene having olefinic unsaturated substituent(s) in an aliphatic liquid, prepolymerizing olefin(s) to produce a prepolymerized solid catalyst and separating from the liquid CHEVRON PHILLIPS CHEMICAL COMPANY LP 2003-03-18 US disclosed
US-20020177676-A1 Method for making and using a metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY LP, A DELAWARE LIMITED PARTNERSHIP 2002-11-28 US disclosed
WO-2002072641-A1 METHOD FOR MAKING AND USING A METALLOCENE CATALYST SYSTEM CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2002-09-19 WO disclosed
WO-1999043724-A1 METHOD FOR POLYMERIZING MONOMERS TO PRODUCE LINEAR, LOW DENSITY POLYMER PHILLIPS PETROLEUM COMPANY (US) 1999-09-02 WO disclosed
EP-0685495-B1 Method for using a supported metallocene catalyst system PHILLIPS PETROLEUM CO (US) 1998-04-08 EP disclosed
EP-0810234-A2 Method for making and using a supported metallocene catalyst system PHILLIPS PETROLEUM COMPANY (US) 1997-12-03 EP disclosed
US-5498581-A OLEFIN POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1996-03-12 US disclosed
EP-0685495-A1 Method for making and using a supported metallocene catalyst system PHILLIPS PETROLEUM COMPANY (US) 1995-12-06 EP disclosed