Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6294447 | 0.97 | TSHR (0.43) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL29255850 | 0.94 | TSHR (0.52) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL5909735 | 0.94 | TSHR (0.52) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL12609397 | 0.94 | TSHR (0.52) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL9559196 | 0.94 | — | — | |
| SCHEMBL692882 | 0.94 | — | — | |
| SCHEMBL29156747 | 0.94 | TSHR (0.52) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL6418651 | 0.94 | TSHR (0.52) | TSHRABCC4MAPTALDH1A1TRPA1 | |
| SCHEMBL5909792 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL7560132 | 0.89 | TSHR (0.48) | TSHRABCC4MAPTALDH1A1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002072641-A1 | METHOD FOR MAKING AND USING A METALLOCENE CATALYST SYSTEM | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2002-09-19 | — | — | WO | disclosed |