Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297665 | 0.86 | HSP90AA1 (0.35) | HSP90AA1MITFADRA2AADRA2BADRA2C | |
| SCHEMBL6293028 | 0.85 | METAP1 (0.41) | HSP90AA1MITFADRA2AADRA2BADRA2C | |
| SCHEMBL6297680 | 0.85 | METAP1 (0.36) | HSP90AA1MITFMCHR1ADRA2AADRA2B | |
| SCHEMBL6294319 | 0.85 | HSP90AA1 (0.36) | HSP90AA1MITFADRA2AADRA2BADRA2C | |
| SCHEMBL6297691 | 0.84 | METAP1 (0.45) | HSP90AA1MITFMCHR1CCR6METAP1 | |
| SCHEMBL6294523 | 0.84 | HSP90AA1 (0.40) | HSP90AA1MITFADRA2AADRA2BADRA2C | |
| SCHEMBL6294309 | 0.79 | SLC6A3 (0.40) | HSP90AA1CCR6METAP1 | |
| SCHEMBL6293251 | 0.77 | METAP1 (0.38) | HSP90AA1MITFADRA2AADRA2BADRA2C | |
| SCHEMBL6293299 | 0.77 | METAP1 (0.46) | HSP90AA1CCR6METAP1 | |
| SCHEMBL6298674 | 0.76 | ADRA2A (0.41) | HSP90AA1MITFADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | claimed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | claimed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | claimed |
| EP-1246791-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001049651-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | claimed |
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | disclosed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | disclosed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | disclosed |
| EP-1246791-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049651-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | CYP2J2, CYP2E1, CYP2D6 | HSP90AA1 1369/4885MITF 2414/4885MCHR1 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.