SCHEMBL6295502

SCHEMBL6295502

O=c1[nH]c2ccccc2c(=O)n1CCCCCO

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.89
HPGD P15428 4/20 0.89
MPO P05164 2/20 0.69
KDM4E B2RXH2 4/20 0.68
HSD17B10 Q99714 3/20 0.68
MAPK1 P28482 1/20 0.68
HDAC3 O15379 1/20 0.60
HDAC4 P56524 1/20 0.60
HDAC1 Q13547 1/20 0.60
HDAC7 Q8WUI4 1/20 0.60
HDAC2 Q92769 1/20 0.60
HDAC10 Q969S8 1/20 0.60
HDAC11 Q96DB2 1/20 0.60
HDAC8 Q9BY41 1/20 0.60
HDAC6 Q9UBN7 1/20 0.60
HDAC9 Q9UKV0 1/20 0.60
HDAC5 Q9UQL6 1/20 0.60
CYP1A2 P05177 1/20 0.59
MAPT P10636 3/20 0.58
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5878601 0.88 ALDH1A1 (0.82) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL6295470 0.85 MPO (0.73) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL6294004 0.85 ALDH1A1 (0.69) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL6293995 0.84 ALDH1A1 (0.68) ALDH1A1HPGDMPOKDM4ESMN1; SMN2
SCHEMBL8652560 0.84 MPO (0.72) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL5553139 0.84 ALDH1A1 (0.71) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL6295501 0.84 MPO (0.72) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL5112012 0.82 ALDH1A1 (0.73) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL8987938 0.82 ALDH1A1 (0.73) ALDH1A1HPGDMPOKDM4EHSD17B10
SCHEMBL14560539 0.82 ALDH1A1 (0.73) ALDH1A1HPGDMPOKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6872727-B1 Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) 2005-03-29 US disclosed
EP-1150964-B1 POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS IBFB GMBH PRIVATES INST FUER B (DE) 2003-10-29 EP disclosed
EP-1150964-A2 POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) 2001-11-07 EP disclosed
WO-2001014344-A2 POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS IBFB GMBH PRIVATES INSTITUT FÜR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) 2001-03-01 WO disclosed