SCHEMBL629608

SCHEMBL629608

COC(OC)(O[C]=O)c1cccc(C)c1C

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.35
ATM Q13315 1/20 0.35
MAPT P10636 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1810457 0.79 TRPA1 (0.38) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL9061534 0.78 TRPA1 (0.35) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL2027830 0.74 CA1 (0.41) ATMTSHR
SCHEMBL10577196 0.74 TRPA1 (0.36) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL3462906 0.72 TRPA1 (0.41) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL2270593 0.70 TRPA1 (0.43) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL628803 0.68 CES1 (0.40) MAPTTSHR
SCHEMBL1483791 0.67 GABRA1 (0.48) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL472173 0.67 GABRA1 (0.48) TRPA1ATMMAPTGABRA1GABRB2
SCHEMBL7312533 0.67 GABRA1 (0.35) GABRA1GABRB2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107002293-B Sequencing by synthesis using pulsed readout optics 艾比斯生物科学公司 2020-12-08 CN claimed
US-20200123605-A1 SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS IBIS BIOSCIENCES, INC. 2020-04-23 US claimed
EP-3194643-B1 SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS IBIS BIOSCIENCES INC (US) 2020-02-19 EP claimed
US-10550428-B2 Sequencing by synthesis using pulse read optics IBIS BIOSCIENCES, INC. (US) 2020-02-04 US claimed
US-20170247755-A1 SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS IBIS BIOSCIENCES, INC. 2017-08-31 US claimed
EP-3194643-A1 SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS Ibis Biosciences, Inc. (US) 2017-07-26 EP claimed
WO-2016044391-A1 SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS IBIS BIOSCIENCES, INC. (US) 2016-03-24 WO claimed
US-8975216-B2 Articles having localized molecules disposed thereon and methods of producing same PACIFIC BIOSCIENCES OF CALIFORNIA (US) 2015-03-10 US claimed
EP-1958955-B1 Spatially addressable oligonucleotide arrays and method of making the same CORNELL RES FOUNDATION INC (US) 2013-09-04 EP claimed
US-7879579-B2 Detection of preferential nucleotide sequences on solid support; generate solid support, incubate with nucleotide sequences, expose to probe, detect signal, presence of signal indicates preferential nucleotide sequences CORNELL RESEARCH FOUNDATION, INC. (US) 2011-02-01 US claimed
EP-0733213-A1 PROCESS FOR THE PRODUCTION OF COMBINATORIAL COMPOUND LIBRARIES Novartis AG (CH) 1996-09-25 EP claimed
US-5510270-A GENERATING PATTERN OF LIGHT AND DARK AREAS BY SELECTIVELY IRRADIATING SURFACE AREAS; DEPROTECTING; CONTACTING WITH RECEPTOR TO IDENTIFY OLIGONUCLEOTIDE SHOWING COMPLEMENTARITY TO RECEPTOR AFFYMAX TECHNOLOGIES N.V. 1996-04-23 US claimed
WO-1995016209-A1 PROCESS FOR THE PRODUCTION OF COMBINATORIAL COMPOUND LIBRARIES CIBA-GEIGY AG (CH) 1995-06-15 WO claimed
US-5424186-A Biosynthesis of oligonucleotides on solid substrate by irradiation of predefined segments to remove blocking agents; then coupling with nucleotide AFFYMAX TECHNOLOGIES N.V. (AN) 1995-06-13 US claimed
US-5412087-A Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces AFFYMAX TECHNOLOGIES N.V. (AN) 1995-05-02 US claimed
EP-0619321-A1 Very large scale immobilized peptide synthesis AFFYMAX TECHNOLOGIES N.V. (AN) 1994-10-12 EP claimed
EP-0476014-B1 VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS AFFYMAX TECH NV (AN) 1994-08-31 EP claimed
WO-1993022680-A1 SPATIALLY-ADDRESSABLE IMMOBILIZATION OF OLIGONUCLEOTIDES AND OTHER BIOLOGICAL POLYMERS ON SURFACES AFFYMAX TECHNOLOGIES N.V. (AN) 1993-11-11 WO claimed
EP-0476014-A1 VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS. AFFYMAX TECH NV (NL) 1992-03-25 EP claimed
WO-1990015070-A1 VERY LARGE SCALE IMMOBILIZED PEPTIDE SYNTHESIS AFFYMAX TECHNOLOGIES N.V. (AN) 1990-12-13 WO claimed