Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536116 | 1.00 | AR (0.47) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL6841601 | 0.83 | AR (0.48) | ARPGRNR3C2ALDH1A1LMNA | |
| SCHEMBL13400874 | 0.83 | AR (0.48) | ARPGRNR3C2ALDH1A1LMNA | |
| SCHEMBL13139936 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL17302786 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL14200096 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL13397495 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL8843324 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL12101456 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 | |
| SCHEMBL12437208 | 0.82 | CYP17A1 (0.54) | ARCYP17A1PGRNR3C2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864248-B2 | Androgenic steroid compounds and a method of making and using the same | RESEARCH TRIANGLE INSTITUTE (US) | 2005-03-08 | — | — | US | disclosed |
| US-6670352-B2 | E.g. 7alpha,11beta-dimethyl-17beta-hydroxyestr-4-en-3-one; controlling male fertility; stereospecific synthesis starting from adrenosterone, and introducing the 7alpha substituent prior to an 11-substituent | RESEARCH TRIANGLE INSTITUTE | 2003-12-30 | — | — | US | disclosed |
| US-20020103177-A1 | Androgenic steroid compounds and a method of making and using the same | COOK C EDGAR (US) | 2002-08-01 | — | — | US | disclosed |
| US-6369047-B2 | ESTR-4-EN-3-ONE DERIVATIVES WITH ENHANCED ACTIVITY RELATIVE TO TESTOSTERONE DUE TO ENHANCED POTENCY; REDUCTION IN SIZE OF SKIN PATCHES | RESEARCH TRIANGLE INSTITUTE | 2002-04-09 | — | — | US | disclosed |
| US-5952319-A | CONTROLLING MALE FERTILITY IN MAMMAL | RESEARCH TRIANGLE INSTITUTE (US) | 1999-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103177-A1 | Androgenic steroid compounds and a method of making and using the same | NR5A1, CYP17A1, SHBG | AR 4/4885CYP17A1 2/4885PGR 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.