Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 1.00 |
| ▸ | FPR3 | P25089 | 2/20 | 0.61 |
| ▸ | TSPO | P30536 | 2/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302106 | 0.93 | CRHR1 (0.87) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6301715 | 0.91 | CRHR1 (0.82) | CRHR1 | |
| SCHEMBL6295510 | 0.82 | CRHR1 (0.69) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL5845873 | 0.81 | CRHR1 (0.69) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL7965099 | 0.80 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL5707848 | 0.76 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL8999349 | 0.76 | CRHR1 (0.67) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL29706373 | 0.76 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL31012286 | 0.75 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Antalarmin SCHEMBL466243 | 0.75 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900217-B2 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC (US) | 2005-05-31 | — | — | US | disclosed |
| US-20050009823-A1 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC | 2005-01-13 | — | — | US | disclosed |
| US-20020151713-A1 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC. | 2002-10-17 | — | — | US | disclosed |
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CHEN YUHPYNG L (US) | 2001-07-12 | — | — | US | disclosed |
| EP-0923582-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008847-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009823-A1 | Substituted 6,5-hetero-bicyclic derivatives | CYP2D6, CYP2B6, ABCG2 | CRHR1 2433/4885FPR3 2071/4885TSPO 3742/4885 |
| US-20020151713-A1 | Substituted 6,5-hetero-bicyclic derivatives | CYP2D6, CYP2B6, CYP3A5 | CRHR1 2304/4885FPR3 2610/4885TSPO 3422/4885 |
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CYP2D6, CYP2B6, CYP3A5 | CRHR1 2026/4885FPR3 2499/4885TSPO 4182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.