Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD1 | O95696 | 1/20 | 0.34 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6299115 | 1.00 | LATS1 (0.35) | LATS1HTR2CHTR2BBRPF1BRD4 | |
| Hydrochloric Acid SCHEMBL6298314 | 0.89 | LATS1 (0.40) | LATS1HTR2CHTR2BGSK3BRAD52 | |
| Hydrochloric Acid SCHEMBL6304604 | 0.89 | LATS1 (0.40) | LATS1HTR2CHTR2BGSK3BRAD52 | |
| Fumaric Acid SCHEMBL6304470 | 0.88 | HTR2C (0.35) | LATS1HTR2CHTR2BBRPF1BRD4 | |
| Fumaric Acid SCHEMBL6299355 | 0.88 | HTR2C (0.35) | LATS1HTR2CHTR2BBRPF1BRD4 | |
| Fumaric Acid SCHEMBL6299353 | 0.88 | HTR2C (0.35) | LATS1HTR2CHTR2BBRPF1BRD4 | |
| Fumaric Acid SCHEMBL6304471 | 0.88 | HTR2C (0.35) | LATS1HTR2CHTR2BBRPF1BRD4 | |
| Fumaric Acid SCHEMBL6305370 | 0.88 | XDH (0.38) | LATS1HTR2CHTR2B | |
| Fumaric Acid SCHEMBL6298247 | 0.88 | XDH (0.38) | LATS1HTR2CHTR2B | |
| Fumaric Acid SCHEMBL6298246 | 0.88 | XDH (0.38) | LATS1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |