Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | AGER | Q15109 | 1/20 | 0.54 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294298 | 0.80 | KDM4E (0.58) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL6366020 | 0.79 | PGR (0.64) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL6293988 | 0.77 | KDM4E (0.56) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL7649524 | 0.74 | TSHR (0.56) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL10760314 | 0.74 | TSHR (0.56) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL9378270 | 0.74 | KDM4E (0.56) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL7017646 | 0.74 | ERCC1 (0.53) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL7649598 | 0.73 | TSHR (0.55) | TSHRHSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL6300121 | 0.73 | PARP1 (0.46) | TSHRHSD17B10SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL6366340 | 0.73 | ERCC1 (0.69) | TSHRHSD17B10KDM4ELMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |