Sugi Predict

Sugi Predict / Compounds / SCHEMBL6299673

SCHEMBL6299673

SCHEMBL6299673

C[C@](Oc1ccc2c(c1CCc1ccccc1)CCCC2=O)(c1ccccc1)c1ncc[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LTB4R Q15722 3/20 0.39
▸ LTB4R2 Q9NPC1 3/20 0.39
▸ MAOA P21397 4/20 0.35
▸ MAOB P27338 4/20 0.35
▸ BRD4 O60885 3/20 0.34
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ TSHR P16473 2/20 0.32
▸ ADRB2 P07550 1/20 0.32
▸ ADRB1 P08588 1/20 0.32
▸ HTR1A P08908 1/20 0.32
▸ ADRB3 P13945 1/20 0.32
▸ SLC6A4 P31645 1/20 0.32
▸ SIGMAR1 Q99720 1/20 0.32
▸ GRM5 P41594 1/20 0.31
▸ PARP1 P09874 1/20 0.31
▸ GABRG2 P18507 1/20 0.31
▸ GABRB3 P28472 1/20 0.31
▸ GABRA5 P31644 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6307035 0.96 LTB4R (0.37) LTB4RLTB4R2MAOAMAOBBRD4
SCHEMBL6301959 0.94 BRD4 (0.38) LTB4RLTB4R2MAOAMAOBBRD4
SCHEMBL6300959 0.94 LTB4R (0.38) LTB4RLTB4R2MAOAMAOBBRD4
SCHEMBL6306125 0.92 LTB4R (0.47) LTB4RLTB4R2BRD4TSHRADRB2
SCHEMBL6306132 0.92 LTB4R (0.47) LTB4RLTB4R2BRD4TSHRADRB2
SCHEMBL6300110 0.92 LTB4R (0.35) LTB4RLTB4R2MAOAMAOBBRD4
SCHEMBL6302034 0.91 BRD4 (0.38) LTB4RLTB4R2BRD4TSHRADRB2
SCHEMBL6299574 0.91 LTB4R (0.34) LTB4RLTB4R2MAOAMAOBBRD4
SCHEMBL6306052 0.91 LTB4R (0.37) LTB4RLTB4R2BRD4MRGPRX4TSHR
SCHEMBL6299727 0.91 LTB4R (0.37) LTB4RLTB4R2MAOAMAOBBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040044057-A1 5- substituted tetralones as inhibitors of ras farnesyl trransferase WARNER-LAMBERT COMPANY 2004-03-04 — — US claimed
US-6943183-B2 5-substituted tetralones as inhibitors of ras farnesyl transferase PFIZER INC (US) 2005-09-13 — — US disclosed
US-20040063770-A1 Method for treating Alzheimer's disease WARNER-LAMBERT COMPANY 2004-04-01 — — US disclosed
US-20040044057-A1 5- substituted tetralones as inhibitors of ras farnesyl trransferase WARNER-LAMBERT COMPANY 2004-03-04 — — US disclosed
US-20010051642-A1 Method for treating Alzheimer's disease AHN KYUNGHYE (US) 2001-12-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063770-A1 Method for treating Alzheimer's disease BACE1, BACE2, PSEN1 LTB4R 1605/4885LTB4R2 1585/4885MAOA 116/4885
US-20010051642-A1 Method for treating Alzheimer's disease BACE1, BACE2, PSEN1 LTB4R 1605/4885LTB4R2 1585/4885MAOA 116/4885
US-20040044057-A1 5- substituted tetralones as inhibitors of ras farnesyl trransferase PTAR1, FNTA, GGPS1 LTB4R 1427/4885LTB4R2 2051/4885MAOA 3197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.