Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 9/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 9/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6300516 | 1.00 | HTR6 (0.34) | HTR6XIAPBIRC2ATRATRIP | |
| Fumaric Acid SCHEMBL6299557 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6299618 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6299615 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6305695 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6299553 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6305697 | 0.88 | MCHR1 (0.33) | XIAPATRATRIPMCHR1PIM1 | |
| Fumaric Acid SCHEMBL6304470 | 0.83 | HTR2C (0.35) | — | |
| Fumaric Acid SCHEMBL6299353 | 0.83 | HTR2C (0.35) | — | |
| Fumaric Acid SCHEMBL6304471 | 0.83 | HTR2C (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |