Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 11/20 | 0.53 |
| ▸ | PTGIR | P43119 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17188814 | 0.85 | WDR5 (0.56) | WDR5PTGIRSMN1; SMN2NLRP3CXCR4 | |
| SCHEMBL6666027 | 0.82 | WDR5 (0.65) | WDR5PTGIRLMNAMEN1SLC22A1 | |
| SCHEMBL13063072 | 0.82 | WDR5 (0.55) | WDR5PTGIRNISCH | |
| SCHEMBL3169468 | 0.81 | PTGIR (0.60) | WDR5PTGIRSMN1; SMN2NLRP3CXCR4 | |
| SCHEMBL6306650 | 0.81 | WDR5 (0.64) | WDR5 | |
| SCHEMBL6664237 | 0.79 | HTR1B (0.61) | WDR5PTGIRGAAADRA2AADRA2B | |
| SCHEMBL10054979 | 0.79 | PTGIR (0.69) | WDR5PTGIRSMN1; SMN2NLRP3CXCR4 | |
| SCHEMBL13063330 | 0.77 | CYP2D6 (0.58) | WDR5PTGIRSMN1; SMN2NLRP3LMNA | |
| SCHEMBL4035161 | 0.75 | PTGIR (0.61) | WDR5PTGIRCXCR4LMNAGAA | |
| SCHEMBL8152769 | 0.75 | WDR5 (0.69) | WDR5PTGIRCYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216866-C | bicyclic vitronectin receptor antagonist compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-31 | — | — | CN | disclosed |
| US-6846833-B2 | Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same | LES LABORATORIES SERVIER (FR) | 2005-01-25 | — | — | US | disclosed |
| EP-1268429-B1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2004-08-18 | — | — | EP | disclosed |
| CN-1411444-A | Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same | SEUWIEL LAB (FR) | 2003-04-16 | — | — | CN | disclosed |
| EP-1268429-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001079172-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER Departament Brevets/Fontanes (FR) | 2001-10-25 | — | — | WO | disclosed |