Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 14/20 | 0.65 |
| ▸ | PTGIR | P43119 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666934 | 0.84 | WDR5 (0.71) | WDR5PTGIR | |
| SCHEMBL13063072 | 0.82 | WDR5 (0.55) | WDR5PTGIRNISCH | |
| SCHEMBL6300545 | 0.82 | WDR5 (0.53) | WDR5PTGIRLMNAADRA2AADRA2B | |
| SCHEMBL17188814 | 0.82 | WDR5 (0.56) | WDR5PTGIRLMNA | |
| SCHEMBL10800812 | 0.81 | PTGIR (0.83) | WDR5PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL3169468 | 0.81 | PTGIR (0.60) | WDR5PTGIRLMNAADRA2AADRA2B | |
| SCHEMBL8152769 | 0.81 | WDR5 (0.69) | WDR5PTGIRCYP2D6HIF1A | |
| SCHEMBL21711673 | 0.80 | WDR5 (1.00) | WDR5 | |
| SCHEMBL21711783 | 0.80 | WDR5 (1.00) | WDR5 | |
| Iodide SCHEMBL3180056 | 0.79 | WDR5 (0.67) | WDR5PTGIRCYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3496724-B1 | PROTEIN KINASE REGULATORS | NANJING GATOR MEDITECH COMPANY LTD (CN) | 2021-10-06 | — | — | EP | disclosed |
| US-11091483-B2 | Protein kinase regulators | Madera Therapeutics, LLC (US) | 2021-08-17 | — | — | US | disclosed |
| US-20190177323-A1 | Protein Kinase Regulators | Madera Therapeutics, LLC | 2019-06-13 | — | — | US | disclosed |
| EP-1296958-A4 | IMINOPYRIMIDINE NMDA NR2B RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002000629-A9 | IMINOPYRIMIDINE NMDA NR2B RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-05-15 | — | — | WO | disclosed |
| EP-1296958-A1 | IMINOPYRIMIDINE NMDA NR2B RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6440976-B2 | FOR THERAPY OF PAIN, MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, STROKE, AND IN THERAPY OF NEUROPATHIES INCLUDING POSTHERPETIC NEURALGIA, CENTRAL PAIN FROM SPINAL CORD INJURY, AND PHANTOM LIMB PAIN | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| US-20020013329-A1 | Iminopyrimidine NMDA NR2B receptor antagonists | MERCK & CO., INC. | 2002-01-31 | — | — | US | disclosed |
| WO-2002000629-A1 | IMINOPYRIMIDINE NMDA NR2B RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091483-B2 | Protein kinase regulators | MAP3K1, MAP3K6, MAP3K20 | WDR5 3431/4885PTGIR 1868/4885LMNA 3613/4885 |
| US-20190177323-A1 | Protein Kinase Regulators | MAP3K1, MAP3K6, MAP3K20 | WDR5 3431/4885PTGIR 1868/4885LMNA 3613/4885 |
| US-20020013329-A1 | Iminopyrimidine NMDA NR2B receptor antagonists | GRIN1, GRIN2B, GRIN2C | WDR5 2268/4885PTGIR 887/4885LMNA 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.