Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.56 |
| ▸ | RXRB | P28702 | 2/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31752544 | 0.88 | KMO (0.95) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL30436085 | 0.88 | KMO (0.95) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL250880 | 0.88 | KMO (0.95) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL28690696 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH | |
| Hydrochloric Acid SCHEMBL30713416 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL28702560 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH | |
| Biphenyl SCHEMBL9652651 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL3220396 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL849169 | 0.86 | KMO (1.00) | KMORXRARXRBHDAC8DHODH | |
| SCHEMBL28708895 | 0.86 | KMO (0.91) | KMORXRARXRBHDAC8DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360716-A | Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer s disease, neurodegeneration and dementia | ASTRAZENECA AB (SE) | 2009-02-04 | — | — | CN | claimed |
| CN-101360716-A | Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer s disease, neurodegeneration and dementia | ASTRAZENECA AB (SE) | 2009-02-04 | — | — | CN | disclosed |
| US-6916837-B2 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them | EISAI CO., LTD. (JP) | 2005-07-12 | — | — | US | disclosed |